I will focus on the serotonin pathway in the intestinal wall as a target system for the effect of these bacteria.
I will also find out how diet drives the kind of bacteria present in our intestine, and how this affects intestinal motility. Finally, I aim to find out which specific substances produced by bacteria help to regulate normal intestinal motility.
Overall, this has huge implications as we can engineer production of these substances by harmless bacteria and develop them as probiotics to regulate normal intestinal motility. Toggle navigation. Recent in Grantomics:.
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Neurophysiologic Mechanisms of Human Large Intestinal Motility — Mayo Clinic
Neurourol Urodyn Mayo Clin Proc Finally, the stomach possesses distinct motility functions during the fasted state. Most importantly, it has developed mechanisms whereby ingested solids that cannot be digested or mechanically dispersed can be expelled from the stomach under normal conditions. This housekeeping function, mediated by a specific motility pattern known as the migrating motor complex or MMC , accounts for the fact that coins or similar objects that are swallowed by small children will eventually be passed in the feces.
From a motility standpoint, the Forgot Password?
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Clinical Sports Medicine Collection. Davis AT Collection. The stomach can be divided into two regions on the basis of motility pattern: an accordian-like reservoir that applies constant pressure on the lumen and a highly contractile grinder.
Read PDF Gastrointestinal Motility: The Integration of Physiological Mechanisms
The upper stomach, composed of the fundus and upper body, shows low frequency, sustained contractions that are responsible for generating a basal pressure within the stomach. Importantly, these tonic contractions also generate a pressure gradient from the stomach to small intestine and are thus responsible for gastric emptrying. Interestingly, swallowing of food and consequent gastric distention inhibits contraction of this region of the stomach, allowing it to balloon out and form a large reservoir without a significant increase in pressure. The lower stomach, composed of the lower body and antrum, develops strong peristaltic waves of contraction that increase in amplitude as they propagate toward the pylorus.
These powerful contractions constitute a very effective gastric grinder; they occur about 3 times per minute in people and 5 to 6 times per minute in dogs.